Neil R Cashman Selected Research

Superoxide Dismutase-1

4/2022	P2X7 receptor activation mediates superoxide dismutase 1 (SOD1) release from murine NSC-34 motor neurons.
1/2020	Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises.
1/2020	Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection.
1/2019	Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis.
1/2019	Therapeutic vaccines for amyotrophic lateral sclerosis directed against disease specific epitopes of superoxide dismutase 1.
1/2019	CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1.
10/2018	Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells.
1/2018	Investigation of Anti-SOD1 Antibodies Yields New Structural Insight into SOD1 Misfolding and Surprising Behavior of the Antibodies Themselves.
1/2018	Prion-like mechanisms in amyotrophic lateral sclerosis.
1/2016	ALS-linked misfolded SOD1 species have divergent impacts on mitochondria.

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Neil R Cashman Research Topics

Disease

28	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 04/2022 - 12/2002
16	Prion Diseases (Transmissible Spongiform Encephalopathies) 10/2016 - 07/2003
15	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2022 - 12/2004
15	Alzheimer Disease (Alzheimer's Disease) 08/2022 - 10/2013
6	Proteostasis Deficiencies 08/2022 - 01/2011
5	Parkinson Disease (Parkinson's Disease) 08/2022 - 01/2014
4	Infections 01/2022 - 03/2010
4	Sarcoma (Soft Tissue Sarcoma) 01/2020 - 01/2012
4	Tauopathies 01/2018 - 01/2011
4	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 06/2014 - 11/2002
3	Chronic Wasting Disease 03/2015 - 07/2006
2	Inflammation (Inflammations) 01/2020 - 12/2019
2	TDP-43 Proteinopathies 01/2019 - 09/2008
2	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2019 - 12/2004
2	Sporadic Creutzfeldt-Jakob Disease 06/2014 - 10/2011
1	Neoplasms (Cancer) 01/2020
1	Amyloid angiopathy 01/2020
1	Craniocerebral Trauma (Head Injury) 07/2017
1	Dystonia (Limb Dystonia) 07/2017
1	Wounds and Injuries (Trauma) 07/2017
1	Virus Diseases (Viral Diseases) 07/2017
1	Shock 07/2017
1	Multiple System Atrophy 01/2017
1	Huntington Disease (Huntington's Disease) 01/2016
1	Scrapie 11/2013
1	Fatal Familial Insomnia 01/2013
1	Liposarcoma 01/2012
1	Brain Diseases (Brain Disorder) 10/2011
1	Infertility (Sterility) 03/2011
1	Persistent Infection 03/2010
1	Communicable Diseases (Infectious Diseases) 03/2010
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 09/2008
1	Gliosis 01/2007
1	Bovine Spongiform Encephalopathy (Mad Cow Disease) 07/2006
1	Mitochondrial Diseases (Mitochondrial Disease) 12/2004
1	Multiple Sclerosis 07/2003
1	Carcinogenesis 04/2003

Drug/Important Bio-Agent (IBA)

26	Proteins (Proteins, Gene)FDA Link 06/2020 - 04/2003
17	Superoxide Dismutase-1IBA 04/2022 - 12/2002
17	PrionsIBA 01/2020 - 07/2006
13	Prion ProteinsIBA 01/2020 - 07/2003
6	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2022 - 09/2008
6	Amyloid (Amyloid Fibrils)IBA 10/2020 - 10/2013
4	AntibodiesIBA 08/2022 - 07/2013
4	Peptides (Polypeptides)IBA 01/2020 - 09/2011
4	Superoxide DismutaseIBA 01/2016 - 12/2002
4	Protein Isoforms (Isoforms)IBA 01/2013 - 11/2002
3	EpitopesIBA 08/2022 - 03/2010
3	VaccinesIBA 01/2019 - 03/2010
2	Amyloid beta-PeptidesIBA 01/2020 - 01/2019
2	Protein AggregatesIBA 01/2016 - 10/2015
2	AntigensIBA 09/2013 - 01/2007
2	Peptide Hydrolases (Proteases)FDA Link 08/2009 - 07/2006
2	ZincIBA 03/2008 - 12/2004
2	CopperIBA 03/2008 - 12/2004
1	SynucleinsIBA 08/2022
1	Cyclic PeptidesIBA 08/2022
1	Pharmaceutical PreparationsIBA 01/2022
1	Viral RNAIBA 01/2022
1	Ribavirin (Virazole)FDA LinkGeneric 01/2022
1	tau Proteins (tau Protein)IBA 10/2020
1	SeleniumIBA 09/2020
1	HDL LipoproteinsIBA 01/2020
1	Carrier Proteins (Binding Protein)IBA 01/2020
1	eIF-2 Kinase (eIF 2 Kinase)IBA 01/2020
1	Scavenger Receptors (Scavenger Receptor)IBA 01/2020
1	ApolipoproteinsIBA 01/2020
1	aducanumabIBA 12/2019
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2019
1	Coffee FDA Link 07/2017
1	Heavy MetalsIBA 07/2017
1	MercuryIBA 07/2017
1	Organic Chemicals (Chemicals, Organic)IBA 07/2017
1	SolventsIBA 07/2017
1	TeaIBA 07/2017
1	Molecular Chaperones (Chaperone, Molecular)IBA 01/2016
1	mesoglycanIBA 12/2014
1	SterolsIBA 09/2011
1	ElementsIBA 09/2011
1	Hormones (Hormone)IBA 03/2011
1	GonadotropinsIBA 03/2011
1	UbiquitinIBA 09/2008
1	Glial Fibrillary Acidic ProteinIBA 01/2007
1	Nucleic AcidsIBA 07/2006
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 12/2004
1	tyrosyltyrosine (Tyr-Tyr)IBA 07/2003
1	Immunoglobulin Variable RegionIBA 07/2003
1	DNA (Deoxyribonucleic Acid)IBA 04/2003
1	Oxidants (Oxidizing Agents)IBA 04/2003
1	Gabapentin (Neurontin)FDA LinkGeneric 03/2003
1	Protons (Proton)IBA 03/2003

Therapy/Procedure

6	Therapeutics 01/2021 - 03/2003
3	Immunotherapy 10/2020 - 03/2010
1	Transplantation 06/2014
1	Operative Surgical Procedures 03/2011
1	Intramuscular Injections 03/2011